Dental inserts of ofloxacin were prepared with objectives of maintain the effective concentration of drug in gingival pocket for prolong period of time and to treat the gingivitis. Biodegradable ofloxacin films were prepared by solvent casting method. The biodegradable inserts were evaluated for drug-excipients interaction, physico-chemical characteristics, polymer degradation, biodegradation of inserts in enzymatic action and in vitro release studies. The weight and thickness of the inserts were in the range of 54.0-59.7 mg and 94.9-95.6 microns, respectively for different formulations. The drug content varied from 10.2-11.4 mg. the biodegradation was evaluated by enzymatic condition. The influence of rate-controlling membrane of different biodegradable polymers of PCL and PLA on release kinetics was studied. The drug release for prepared formulations with rate-controlling membrane of PCL and PCL was found to be 74.10-75.2 and 79.64-80.92 % respectively and followed zero-order kinetics. PCL-ofloxacin biodegradable inserts are promising delivery for treatment of gingivitis for prolong period.
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